A Tissue Factor Influencing Succinic Dehydrogenase Activity in Tuberculous Guinea Pigs
نویسندگان
چکیده
The alterations in succinic dehydrogenase activity during the course of infection with Mycobacterium tuberculosis strains H37Rv and BCG, as well as with dead bacilli, has been described. A tissue factor has been described which is prepared from normal bovine kidney and will restore enzyme activity in vitro. This factor is prepared by chromatographic analysis and contains a nucleotide with an ultraviolet absorption maxima at 250 mmicro (pH 3) and a free sulfhydryl group. The role of this factor in the response to tuberculosis is discussed.
منابع مشابه
Effect of Infection with M. Tuberculosis and of Tuberculin Shock on the Succinic Dehydrogenase Activity of Guinea Pig Tissues
The kidney of guinea pigs infected with the H37Rv and BCG strains of M. tuberculosis showed a diminution in succinic dehydrogenase activity when measured by the tetrazolium technique. This effect was also seen in the liver and spleen of animals infected with the BCG strain. Sensitized animals showed similar results when given tuberculin in sublethal doses. The succinic oxidase was also low in t...
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 101 شماره
صفحات -
تاریخ انتشار 1955